POLICE are investigating what led to the fatal collision in Orbost on Monday morning.
The collision occurred between a van and a four-wheel-drive at the intersection of the Princes Highway and Salisbury St about 8.55am.
The driver and single occupant of the van died at the scene.
The driver of the 4WD and passenger were conveyed to Orbost Hospital by ambulance.
The east bound lanes of the Princes Highway were currently closed with all traffic using the west bound lanes at a reduced speed limit.
Witnesses have been urged to phone Crime Stoppers on 1800 333 000 or submit a confidential crime report at www.crimestoppersvic.com.au