THE Princes Highway between Flynn and Rosedale was closed Thursday morning following a three vehicle collision about 7.15am.
Police said after a utility and station wagon collided head on, a truck driver tried to avoid hitting them and rolled.
The driver of the utility was taken to Latrobe Regional Hospital with serious injuries, while the driver and occupant of the station wagon were taken to the same hospital with minor injuries.
The truck driver was not injured.
People with information are urged to phone Sale police on 5142 2200 or to remain anonymous, phone Crime Stoppers on 1800 333 000.